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Article

Detection of single nucleotide polymorphisms using a biosensor-containing titanium-well array.

Journal of nanoscience and nanotechnology - 1 Jan 2013

Lee Joo-Kyung, Cho Si-Hyeong, Lee Jinyoung, Lee Jung-Hwan, Kim Ah Young, Park Bae Ho, Park Jin-Goo, Busnaina Ahmed, Lee Hea Yeon

Abstract excerpt

The rapid identification and verification of single nucleotide polymorphisms (SNPs) were demonstrated using a well array sensor containing anti-biofouling titanium (Ti). Probe single-stranded DNA (ssDNA) was immobilized inside a titanium-well array on amine-modified glass surfaces with anti-biofouling behavior via a streptavidin-biotin interaction. Fluorescence intensity changes originating from the hybridization...

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Identifiers

PMID: 23646708
DOI: 10.1166/jnn.2013.6865

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