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Article

Variable antigen genes of the relapsing fever agent Borrelia hermsii are activated by promoter addition

1 Feb 1991

Abstract excerpt

Borrelia hermsii, an agent of relapsing fever, avoids the host's immune response by means of multiphasic antigenic variation. Serotype specificity is determined by variable antigens called the Vmp lipoproteins. Through recombination between linear plasmids a formerly silent vmp gene replaces another vmp gene at a telomeric expression locus. We examined strain HS1 borreliae before and after a switch from serotype...

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PMID: 2041480
DOI: 10.1111/j.1365-2958.1991.tb02132.x

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