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Article

Antigen diversity in the bacterium B. hermsii through "somatic" mutations in rearranged vmp genes.

Cell - 9 Sept 1994

Restrepo B I, Barbour A G

Abstract excerpt

B. hermsii counters host immunity with multiphasic antigenic variation. This is conferred by interplasmidic and intraplasmidic rearrangements of vmp genes. In several independent events, activation of a silent vmp gene through intraplasmidic deletions but not interplasmidic recombinations was followed by the appearance at its 5' end of multiple mutations that were not present in the silent gene. The prevalence of...

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PMID: 8087853
DOI: 10.1016/s0092-8674(94)90642-4

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