Antigen diversity in the bacterium B. hermsii through "somatic" mutations in rearranged vmp genes.

doi:10.1016/s0092-8674(94)90642-4

Back to search

Article

Antigen diversity in the bacterium B. hermsii through "somatic" mutations in rearranged vmp genes.

Cell - 9 Sept 1994

Restrepo B I, Barbour A G

Abstract excerpt

B. hermsii counters host immunity with multiphasic antigenic variation. This is conferred by interplasmidic and intraplasmidic rearrangements of vmp genes. In several independent events, activation of a silent vmp gene through intraplasmidic deletions but not interplasmidic recombinations was fol...

Topics

Animals
Antigens, Bacterial
Bacterial Proteins
Base Sequence
Borrelia
Gene Rearrangement
Genes, Bacterial
Genes, Switch
Genetic Variation
Mice
Models, Genetic
Molecular Sequence Data
Mutation
Plasmids
Relapsing Fever
Serotyping
Time Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.