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Article

Subtelomeric expression regions of <i>Borrelia hermsii</i> linear plasmids are highly polymorphic

1 Nov 1992

Abstract excerpt

Borrelia hermsii, a relapsing fever agent, undergoes multiphasic antigenic variation to evade its host's immune response. Serotype specificity is determined by variable membrane lipoproteins, Vmps, which are expressed from genes located near the end of a linear plasmid. Using the polymerase chain reaction and primers representing the promoter of the active vmp and a conserved telomeric sequence, we characterized...

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PMID: 1484486
DOI: 10.1111/j.1365-2958.1992.tb02198.x

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