Article
Juxtaposition of expressed variable antigen genes with a conserved telomere in the bacterium Borrelia hermsii.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Kitten T, Barbour A G
Abstract excerpt
Borrelia hermsii, an agent of relapsing fever, survives in mammals through antigenic variation. Change in serotype-specific variable outer membrane proteins (Vmps) occurs when a Vmp gene at an expression site is replaced with a previously silent gene for another Vmp. Silent and active genes are o...
Topics
- Antigens, Bacterial
- Base Sequence
- Blotting, Southern
- Borrelia
- Chromosomes, Bacterial
- Cloning, Molecular
- DNA, Bacterial
- Genes, Bacterial
- Genetic Linkage
- Genetic Variation
- Molecular Sequence Data
- Plasmids
- Restriction Mapping
- Sequence Homology, Nucleic Acid