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Article

Juxtaposition of expressed variable antigen genes with a conserved telomere in the bacterium Borrelia hermsii.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Kitten T, Barbour A G

Abstract excerpt

Borrelia hermsii, an agent of relapsing fever, survives in mammals through antigenic variation. Change in serotype-specific variable outer membrane proteins (Vmps) occurs when a Vmp gene at an expression site is replaced with a previously silent gene for another Vmp. Silent and active genes are on separate linear plasmids. The upstream site for a nonreciprocal recombination between two linear plasmids is near the...

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Identifiers

PMID: 2385585
DOI: 10.1073/pnas.87.16.6077
PMCID: PMC54475

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