Antigenic variation by <i>Borrelia hermsii</i> occurs through recombination between extragenic repetitive elements on linear plasmids

Abstract excerpt

The relapsing fever agent Borrelia hermsii undergoes multiphasic antigenic variation through gene conversion of a unique expression site on a linear plasmid by an archived variable antigen gene. To further characterize this mechanism we assessed the repertoire and organization of archived variable antigen genes by sequencing approximately 85% of plasmids bearing these genes. Most archived genes shared with the...

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