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Article

Conditional random pattern model for copy number aberration detection.

BMC bioinformatics - 22 Apr 2010

Li Fuhai, Zhou Xiaobo, Huang Wanting, Chang Chung-Che, Wong Stephen T C

Abstract excerpt

BACKGROUND: DNA copy number aberration (CNA) is very important in the pathogenesis of tumors and other diseases. For example, CNAs may result in suppression of anti-oncogenes and activation of oncogenes, which would cause certain types of cancers. High density single nucleotide polymorphism (SNP) array data is widely used for the CNA detection. However, it is nontrivial to detect the CNA automatically because the...

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PMID: 20412592
DOI: 10.1186/1471-2105-11-200
PMCID: PMC2876128

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