Article
Epigenetic gene promoter methylation at birth is associated with child's later adiposity.
Diabetes - 1 May 2011
Godfrey Keith M, Sheppard Allan, Gluckman Peter D, Lillycrop Karen A, Burdge Graham C, McLean Cameron, Rodford Joanne, Slater-Jefferies Joanne L, Garratt Emma, Crozier Sarah R, Emerald B Starling, Gale Catharine R, Inskip Hazel M, Cooper Cyrus, Hanson Mark A
Abstract excerpt
OBJECTIVE: Fixed genomic variation explains only a small proportion of the risk of adiposity. In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans. RESEARCH DESIGN AND METHODS: Using Sequenom MassARRAY we measured the methylation status of 68 CpGs 5' from five candidate genes...
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