Article
Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes.
Biogerontology - 1 Aug 2010
Laplana Marina, Sánchez-de-la-Torre Manuel, Aguiló Alicia, Casado Ignasi, Flores Miquel, Sánchez-Pellicer Ramon, Fibla Joan
Abstract excerpt
Longevity is a complex phenomenon involving multiple environmental and biological factors. Genetic studies of longevity have focussed on DNA repair, oxidative damage correction and immune-related genes. Vitamin-D works by modulating mineral homeostasis and key physiological processes such as cell proliferation and immune response. Vitamin-D insufficiency has been largely considered a risk factor for life-limiting...
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