Article
The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template.
Nucleic acids research - 1 Oct 2010
Coustry Françoise, Oh Chun-do, Hattori Takako, Maity Sankar N, de Crombrugghe Benoit, Yasuda Hideyo
Abstract excerpt
Mutations in SOX9, a gene essential for chondrocyte differentiation cause the human disease campomelic dysplasia (CD). To understand how SOX9 activates transcription, we characterized the DNA binding and cell-free transcription ability of wild-type SOX9 and a dimerization domain SOX9 mutant. Whereas formation of monomeric mutant SOX9-DNA complex increased linearly with increasing SOX9 concentrations, formation of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.