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Cys303 in the histidine kinase PhoR is crucial for the phosphotransfer reaction in the PhoPR two-component system in Bacillus subtilis.

Journal of bacteriology - 1 Jan 2007

Eldakak Amr, Hulett F Marion

Abstract excerpt

The PhoPR two-component system activates or represses Pho regulon genes to overcome a phosphate deficiency. The Pho signal transduction network is comprised of three two-component systems, PhoPR, ResDE, and Spo0A. Activated PhoP is required for expression of ResDE from the resA promoter, while ResD is essential for 80% of Pho induction, establishing a positive feedback loop between these two-component systems to...

Topics

Alanine
Bacillus subtilis
Bacterial Proteins
Cysteine
Dithiothreitol
Electrophoresis, Polyacrylamide Gel
Gene Expression Regulation, Bacterial
Histidine Kinase
Mutation
Operon
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Protein Kinases

Signal Transduction

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Open in PubMed Open full text

Identifiers

PMID: 17085571
DOI: 10.1128/JB.01205-06
PMCID: PMC1797398

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Cys303 in the histidine kinase PhoR is crucial for the phosphotransfer reaction in the PhoPR two-component system in Bacillus subtilis.PMID 17085571Read ↗

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