Article
Sensing of cytoplasmic pH by bacterial chemoreceptors involves the linker region that connects the membrane-spanning and the signal-modulating helices.
The Journal of biological chemistry - 11 Jan 2002
Umemura Tohru, Matsumoto Yumi, Ohnishi Kouhei, Homma Michio, Kawagishi Ikuro
Abstract excerpt
The two major chemoreceptors of Escherichia coli, Tsr and Tar, mediate opposite responses to the same changes in cytoplasmic pH (pH(i)). We set out to identify residues involved in pH(i) sensing to gain insight into the general mechanisms of signaling employed by the chemoreceptors. Characterization of various chimeras of Tsr and Tar localized the pH(i)-sensing region to Arg(259)-His(267) of Tar and...
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