Article
The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.
Microbiology (Reading, England) - 1 Mar 2009
Gooderham W James, Gellatly Shaan L, Sanschagrin François, McPhee Joseph B, Bains Manjeet, Cosseau Celine, Levesque Roger C, Hancock Robert E W
Abstract excerpt
Pseudomonas aeruginosa is a ubiquitous environmental Gram-negative bacterium that is also a major opportunistic human pathogen in nosocomial infections and cystic fibrosis chronic lung infections. PhoP-PhoQ is a two-component regulatory system that has been identified as essential for virulence and cationic antimicrobial peptide resistance in several other Gram-negative bacteria. This study demonstrated that...
Topics
- Animals
- Bacterial Proteins
- Biofilms
- Cell Line, Transformed
- Gene Expression Regulation, Bacterial
- Humans
- Male
- Microbial Sensitivity Tests
- Mutation
- Oligonucleotide Array Sequence Analysis