Article
Polymorphisms of HLA-DR and -DQ genes in Japanese patients with bullous pemphigoid.
The Journal of dermatology - 1 Mar 2000
Okazaki A, Miyagawa S, Yamashina Y, Kitamura W, Shirai T
Abstract excerpt
Bullous pemphigoid (BP), an autoimmune skin disease of the elderly, is mediated by autoantibodies that bind to hemidesmosomes of epidermal basal cells. This study investigated BP-associated HLA-DR and -DQ genes among Japanese patients. We analyzed HLA-DR and -DQ genes among 23 Japanese BP patients based on the polymerase chain reaction-restriction fragment length polymorphism. Eighteen of these 23 patients (78%)...
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