Article

Non-coding exon splicing orchestrates tissue-specific expression of two functionally distinct mitochondrial isoforms of Mitofusin 2

2025-09-27

Abstract excerpt

<h4>ABSTRACT</h4> In mammals, outer mitochondrial membrane fusion controls mitochondrial network morphology, promotes subcellular trafficking and ensures proper mitochondrial content mixing. This process is controlled by two homologous dynamin related proteins, MFN1 and MFN2, which are ubiquitously expressed across tissues. Intriguingly, in humans, loss of function of MFN2 is responsible for the Charcot-Marie-Too...

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Literature Corpus work: 8ab7f3cb-06a4-519f-bcde-822e91817f43
DOI: 10.1101/2025.09.26.678759

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