Article
The polybasic sequence in the C2B domain of rabphilin is required for the vesicle docking step in PC12 cells.
Journal of neurochemistry - 1 Feb 2007
Tsuboi Takashi, Kanno Eiko, Fukuda Mitsunori
Abstract excerpt
Rabphilin is generally thought to be involved in the regulation of secretory vesicle exocytosis in neurons and neuroendocrine cells, and it has recently been hypothesized that the C2B domain of rabphilin promotes the docking of dense-core vesicles to the plasma membrane through simultaneous interaction with a vesicle protein, Rab3A/27A, and a plasma membrane protein, SNAP-25 (synaptosome-associated protein of 25...
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