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Article

DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer.

The Journal of biological chemistry - 11 Apr 2014

Kabekkodu Shama Prasada, Bhat Samatha, Radhakrishnan Raghu, Aithal Abhijit, Mascarenhas Roshan, Pandey Deeksha, Rai Lavanya, Kushtagi Pralhad, Mundyat Gopinath Puthiya, Satyamoorthy Kapaettu

Abstract excerpt

Double C2-like domain β (DOC2B) gene encodes for a calcium-binding protein, which is involved in neurotransmitter release, sorting, and exocytosis. We have identified the promoter region of the DOC2B gene as hypermethylated in pre-malignant, malignant cervical tissues, and cervical cancer cell lines by methylation-sensitive dimethyl sulfoxide-polymerase chain reaction and bisulfite genome sequencing; whereas, it...

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Identifiers

PMID: 24570007
DOI: 10.1074/jbc.M113.491506
PMCID: PMC4036182

Genes

AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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