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Article

Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.

Gastroenterology - 1 Jul 2010

Gradilone Sergio A, Masyuk Tatyana V, Huang Bing Q, Banales Jesus M, Lehmann Guillermo L, Radtke Brynn N, Stroope Angela, Masyuk Anatoliy I, Splinter Patrick L, LaRusso Nicholas F

Abstract excerpt

BACKGROUND & AIMS: In polycystic liver diseases, cyst formation involves cholangiocyte hyperproliferation. In polycystic kidney (PCK) rats, an animal model of autosomal-recessive polycystic kidney disease (ARPKD), decreased intracellular calcium [Ca(2+)](i) in cholangiocytes is associated with hyperproliferation. We recently showed transient receptor potential vanilloid 4 (Trpv4), a calcium-entry channel, is...

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Identifiers

PMID: 20399209
DOI: 10.1053/j.gastro.2010.04.010
PMCID: PMC2902576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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