Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells

16 Apr 2010

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors with a dismal prognosis and no effective conservative therapeutic strategies. Although it is demonstrated that histone deacetylases (HDACs), especially the class I HDACs HDAC1, 2 and 3 are highly expressed in this disease, little is known about HDAC isoenzyme specific functions. RESULTS: Depletion of HDAC2, but not HDAC1, in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Cytokine Signaling Pathways and Interactions
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20398369
DOI: 10.1186/1476-4598-9-80

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cellsPMID 20398369Read ↗

Class I and Class II Histone Deacetylases Are Potential Therapeutic Targets for Treating Pancreatic CancerSemantic proximity Read ↗

c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cellsSemantic proximity Read ↗

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.Semantic proximity Read ↗

NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancerSemantic proximity Read ↗

An Epigenetic Approach to Pancreatic Cancer Treatment: The Prospective Role of Histone Deacetylase InhibitorsSemantic proximity Read ↗

Negative control of TRAIL-R1 signaling by transforming growth factor β1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1.Semantic proximity Read ↗

HDAC Inhibition Sensitizes Pancreatic Tumors to DNA Damage by Global Redistribution of the Transcriptional MachinerySemantic proximity Read ↗

HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer CellsSemantic proximity Read ↗

HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer.Semantic proximity Read ↗

A novel TRAIL mutant-TRAIL-Mu3 enhances the antitumor effects by the increased affinity and the up-expression of DR5 in pancreatic cancer.Semantic proximity Read ↗

Proteasome Inhibition Results in TRAIL Sensitization of Primary Keratinocytes by Removing the Resistance-Mediating Block of Effector Caspase MaturationSemantic proximity Read ↗

Histone Deacetylase Inhibitors Sensitize TRAIL-Induced Apoptosis in Colon Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.