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Article

Structure-function analysis of mutant RNA-dependent RNA polymerase complexes with VPg.

Biochemistry. Biokhimiia - 1 Oct 2009

Gu Chaojiang, Zeng Tao, Li Yong, Xu Zhenghui, Mo Zhongxi, Zheng Congyi

Abstract excerpt

The replication of the foot-and-mouth disease virus (FMDV) genome is critically dependent upon the activity of a virally encoded RNA-dependent RNA polymerase (RdRp). In this study, four mutant RdRps of FMDV were isolated from viral quasi-species treated with ribavirin, of which two were single mutants (L123F and T381A) and two were double mutants (T291I/T381I and L123F/F244L). The mutant proteins were expressed...

Topics

Animals
Mutation
Protein Structure, Tertiary
RNA-Dependent RNA Polymerase
Substrate Specificity
Viral Nonstructural Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19916926
DOI: 10.1134/s0006297909100095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19916926-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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