Article
Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model.
Journal of hepatology - 1 Jun 2010
Shindo Nobuyasu, Fujisawa Tomomi, Sugimoto Ken, Nojima Koji, Oze-Fukai Aya, Yoshikawa Yuki, Wang Xiang, Yasuda Osamu, Ikegami Hiroshi, Rakugi Hiromi
Abstract excerpt
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is currently recognized as a global health issue and encompasses a wide spectrum of entities, ranging from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH). The lack of a spontaneous animal model of NASH, however, has hampered basic research in this field. METHODS: We examined the hepatic lesions in the inbred Fatty Liver Shionogi (FLS)...
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