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Article

Spontaneous development of hepatocellular carcinomas in the FLS mice with hereditary fatty liver.

Cancer letters - 30 Jun 2003

Soga Masahiko, Kishimoto Yoshio, Kawamura Yoshihiro, Inagaki Shuichiro, Makino Susumu, Saibara Toshiji

Abstract excerpt

The fatty liver Shionogi (FLS) mouse is an inbred strain that develops spontaneous fatty liver (hepatic steatosis) chronically without obesity. Here, we reported that the mice develop spontaneous hepatocellular tumors with high incidences. The mice with age of over 1 year frequently developed whitish protuberant nodules in the livers, which were histologically diagnosed as hepatocellular adenoma and/or carcinoma...

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Identifiers

PMID: 12860288
DOI: 10.1016/s0304-3835(03)00213-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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