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Article

Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.

The EMBO journal - 5 May 2010

Miyazono Ken-ichi, Zhi Yuehua, Takamura Yuriko, Nagata Koji, Saigo Kaoru, Kojima Tetsuya, Tanokura Masaru

Abstract excerpt

To achieve accurate gene regulation, some homeodomain proteins bind cooperatively to DNA to increase those site specificities. We report a ternary complex structure containing two homeodomain proteins, aristaless (Al) and clawless (Cll), bound to DNA. Our results show that the extended conserved sequences of the Cll homeodomain are indispensable to cooperative DNA binding. In the Al-Cll-DNA complex structure, the...

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Identifiers

PMID: 20389279
DOI: 10.1038/emboj.2010.53
PMCID: PMC2876955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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