Article
HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.
The Journal of clinical investigation - 1 May 2010
Gilbert Penney M, Mouw Janna K, Unger Meredith A, Lakins Johnathon N, Gbegnon Mawuse K, Clemmer Virginia B, Benezra Miriam, Licht Jonathan D, Boudreau Nancy J, Tsai Kelvin K C, Welm Alana L, Feldman Michael D, Weber Barbara L, Weaver Valerie M
Abstract excerpt
Breast cancer 1, early onset (BRCA1) expression is often reduced in sporadic breast tumors, even in the absence of BRCA1 genetic modifications, but the molecular basis for this is unknown. In this study, we identified homeobox A9 (HOXA9) as a gene frequently downregulated in human breast cancers and tumor cell lines and noted that reduced HOXA9 transcript levels associated with tumor aggression, metastasis, and...
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