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Article

EGFR: An essential receptor tyrosine kinase-regulator of cancer stem cells.

Advances in cancer research - 1 Jan 2020

Talukdar Sarmistha, Emdad Luni, Das Swadesh K, Fisher Paul B

Abstract excerpt

The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated levels in different forms of cancer and expression often correlates positively with cancer progression and poor prognosis. Different mutant forms of this protein also contribute to cancer heterogeneity. A constitutively active form of EGFR, EGFRvIII is one of the most important variants. EGFR is responsible for the maintenance and...

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PMID: 32593400
DOI: 10.1016/bs.acr.2020.04.003

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