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Article

A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2007

Leaphart Cynthia L, Cavallo Jaime, Gribar Steven C, Cetin Selma, Li Jun, Branca Maria F, Dubowski Theresa D, Sodhi Chhinder P, Hackam David J

Abstract excerpt

Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in preterm infants and is characterized by translocation of LPS across the inflamed intestine. We hypothesized that the LPS receptor (TLR4) plays a critical role in NEC development, and we sought to determine the mechanisms involved. We now demonstrate that NEC in mice and humans is associated with increased expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17878380
DOI: 10.4049/jimmunol.179.7.4808

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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