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Article

The phenotype of necrotizing enterocolitis correlates with distinct changes of intestinal junctional proteins.

Pathology, research and practice - 1 Jan 2025

Kollmann Catherine, Niklas Carolin, Ernestus Karen, Hiller Grit Gr, Hörner Marius, Burkard Natalie, Germer Christoph-Thomas, Härtel Christoph, Meyer Thomas, Bartfeld Sina, Glaser Kirsten, Schlegel Nicolas

Abstract excerpt

Necrotizing enterocolitis (NEC) is a major cause of mortality in preterm infants. Its pathophysiology remains poorly understood but intestinal epithelial barrier dysfunction contributes to the disease. We characterized junctional proteins in intestinal specimens from preterm infants. Samples from 27 patients with NEC and 20 patients with focal intestinal perforation (FIP) from the center of the specimens...

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PMID: 39579526
DOI: 10.1016/j.prp.2024.155731

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