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Article

The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006

Jilling Tamas, Simon Dyan, Lu Jing, Meng Fan Jing, Li Dan, Schy Robert, Thomson Richard B, Soliman Antoine, Arditi Moshe, Caplan Michael S

Abstract excerpt

Bacteria are thought to contribute to the pathogenesis of necrotizing enterocolitis (NEC), but it is unknown whether their interaction with the epithelium can participate in the initiation of mucosal injury or they can act only following translocation across a damaged intestinal barrier. Our aims were to determine whether bacteria and intestinal epithelial TLR4 play roles in a well-established neonatal rat model...

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Source

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Identifiers

PMID: 16920968
DOI: 10.4049/jimmunol.177.5.3273
PMCID: PMC2697969

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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