Article
The wound environment as a regulator of fibroblast phenotype.
The Journal of surgical research - 1 May 1991
Regan M C, Kirk S J, Wasserkrug H L, Barbul A
Abstract excerpt
Fibroblasts are fundamental to successful wound healing. We hypothesized that the induction and regulation of various fibroblast functions (proliferation, collagen synthesis, and remodeling) are determined by the wound environment. We examined the effect of wound fluid (WF), as a reflection of the wound environment, on the phenotypic expression of normal dermal (NF) and wound-harvested fibroblasts (WHF). WF and...
Topics
- Animals
- Body Fluids
- Collagen
- Fibroblasts
- Male
- Phenotype
- Protein Biosynthesis
- Rats
- Rats, Inbred Lew
- Skin
- Wound Healing