Phenotypic differences in cytokine responsiveness of hypertrophic scar versus normal dermal fibroblasts.

doi:10.1111/1523-1747.ep12371710

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Phenotypic differences in cytokine responsiveness of hypertrophic scar versus normal dermal fibroblasts.

The Journal of investigative dermatology - 1 Dec 1993

Garner W L, Karmiol S, Rodriguez J L, Smith D J, Phan S H

Abstract excerpt

The alteration of normal dermal fibroblast function that leads to the development of hypertrophic scar after thermal injury is unknown. To determine functional differences that might explain this process, fibroblasts were cultured from biopsies of post-thermal injury mature hypertrophic scars and patient-matched normal skin. The mitogenic responses of scar cells to fetal bovine serum, epidermal growth factor...

Topics

Adolescent
Adult
Aged
Child
Cicatrix, Hypertrophic
Collagen
Cytokines
Epidermal Growth Factor
Female
Fibroblasts
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mitogens

Phenotype

Platelet-Derived Growth Factor

Skin

Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 8245516
DOI: 10.1111/1523-1747.ep12371710

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8245516-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic differences in cytokine responsiveness of hypertrophic scar versus normal dermal fibroblasts.PMID 8245516Read ↗

Analysis of Hypertrophic and Normal Scar Gene Expression With cDNA MicroarraysSemantic proximity Read ↗

Differential expression and regulation of extracellular matrix‐associated genes in fetal and neonatal fibroblastsSemantic proximity Read ↗

How is Type I procollagen synthesis regulated at the gene level during tissue fibrosisSemantic proximity Read ↗

The wound environment as a regulator of fibroblast phenotype.Semantic proximity Read ↗

Gene Expression of Early Hypertrophic Scar Tissue Screened by Means of cDNA MicroarraysSemantic proximity Read ↗

A model of scarless human fetal wound repair is deficient in transforming growth factor betaSemantic proximity Read ↗

Keratinocyte regulation of TGF‐β and connective tissue growth factor expression: A role in suppression of scar tissue formationSemantic proximity Read ↗

[Effects and mechanism of age on the stiffness and the fibrotic phenotype of fibroblasts of human hypertrophic scar].Semantic proximity Read ↗

Differential gene expression in response to transforming growth factor‐β1 by fetal and postnatal dermal fibroblastsSemantic proximity Read ↗

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healingSemantic proximity Read ↗

Characterization of human vocal fold fibroblasts derived from chronic scarSemantic proximity Read ↗

Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.