Hypercalcemia induces a proinflammatory phenotype in rat leukocytes and endothelial cells.

Abstract excerpt

Endothelial plasma membrane lipid microdomains, so called lipid rafts/caveolae, are rich in neutral glycosphingolipid, globotriaosylceramide, Gb3Cer, or CD77. Several plasma membrane Ca(2+) channels and pumps are located in lipid rafts/caveolae. Increased Ca(2+) influx could cause the development of an endothelial proinflammatory phenotype. Therefore, the aim of this study was to estimate the effects of...

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