Article
The UGT1A1*28 genotype and the toxicity of low-dose irinotecan in patients with advanced lung cancer.
Oncology research - 1 Jan 2010
Sugiyama Tomohide, Hirose Takashi, Kusumoto Sojiro, Shirai Takao, Yamaoka Toshimitsu, Okuda Kentaro, Ohnishi Tsukasa, Ohmori Tohru, Adachi Mitsuru
Abstract excerpt
The association between the UGT1A1*28 genotype and the severe toxicity of low-dose irinotecan has been controversial, and few studies have examined this association in patients with lung cancer. The aim of this study was to assess the association between the UGT1A1*28 genotype and the severe toxicity of low-dose irinotecan in Japanese patients with lung cancer. From December 2005 through July 2008, 53 Japanese...
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