Article
Cross-linking mass spectrometry and structural modeling identifies compact conformation of DENV NS2B cofactor region bound to NS3.
Structure (London, England : 1993) - 5 Mar 2026
Ser Zheng, Phoo Wint Wint, Fyn Teo Chwee Fang, Wong Sook Yi, Choy Milly M, Marzinek Jan K, Zheng Yushu, Al-Hakim Wan Luqman, Mohd Mazlan Muhammad Danial Bin, Wong Valencia Zi Qing, Chan Kitti Wing Ki, Bond Peter J, Luo Dahai, Vasudevan Subhash G, Sobota Radoslaw M
Abstract excerpt
Dengue virus infection remains a public health threat. Dengue NS2B-NS3 proteins are prime antiviral drug targets, highly dynamic, and adopt different structural conformations. We combine cross-linking mass spectrometry (XL-MS), molecular dynamics (MD) simulations, and biochemical assays to identify NS2B-NS3 full length interactions. Using cross-linkers of different lengths as molecular rulers, we identified NS2B...
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