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Article

Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells.

The Journal of biological chemistry - 11 Jun 2010

Feng Qiyu, Baird Dan, Yoo Sungsoo, Antonyak Marc, Cerione Richard A

Abstract excerpt

Previously we showed that Cool-1 (Cloned out of library-1)/beta-Pix (Pak-interactive exchange factor) is phosphorylated at a specific tyrosine residue (Tyr-442) in a Src-dependent manner and serves as a dual function guanine nucleotide exchange factor (GEF)/signaling-effector for Cdc42 that is es...

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Identifiers

PMID: 20375009
DOI: 10.1074/jbc.M109.098079
PMCID: PMC2881803

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20375009-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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