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Article

INSIG2 polymorphism and weight gain, dyslipidemia and serum adiponectin in Finnish patients with schizophrenia treated with clozapine.

Pharmacogenomics - 1 Dec 2016

Koskinen Suvi, Kampman Olli, Solismaa Anssi, Lyytikäinen Leo-Pekka, Seppälä Niko, Viikki Merja, Hämäläinen Mari, Moilanen Eeva, Mononen Nina, Lehtimäki Terho, Leinonen Esa

Abstract excerpt

AIM: To investigate INSIG2's association with obesity, weight change and serum lipid profile during clozapine treatment. MATERIALS & METHODS: Subjects with schizophrenia (n = 190) were genotyped, identifying seven SNPs. Genetic risk scores (GRSs) were calculated to adiponectin, high-density lipoprotein cholesterol, triglycerides and weight gain. RESULTS: In the model for weight gain, SNPs rs12151787, rs17047733...

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Source

Identifiers

PMID: 27885961
DOI: 10.2217/pgs-2016-0117

Genes

INSIG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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