Article
Optic atrophy 3 as a protein of the mitochondrial outer membrane induces mitochondrial fragmentation.
Cellular and molecular life sciences : CMLS - 1 Aug 2010
Ryu Seung-Wook, Jeong Hyeon Joo, Choi Myunghwan, Karbowski Mariusz, Choi Chulhee
Abstract excerpt
The optic atrophy 3 (OPA3) gene, which has no known homolog or biological function, is mutated in patients with hereditary optic neuropathies. Here, we identified OPA3 as an integral protein of the mitochondrial outer membrane (MOM), with a C-terminus exposed to the cytosol and an N-terminal mitochondrial targeting domain. By quantitative analysis, we demonstrated that overexpression of OPA3 significantly induced...
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