Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of OPA1 mutations on mitochondrial morphology and apoptosis: relevance to ADOA pathogenesis.

Journal of cellular physiology - 1 May 2007

Olichon Aurélien, Landes Thomas, Arnauné-Pelloquin Laetitia, Emorine Laurent J, Mils Valérie, Guichet Agnès, Delettre Cécile, Hamel Christian, Amati-Bonneau Patrizia, Bonneau Dominique, Reynier Pascal, Lenaers Guy, Belenguer Pascale

Abstract excerpt

To characterize the molecular links between type-1 autosomal dominant optic atrophy (ADOA) and OPA1 dysfunctions, the effects of pathogenic alleles of this dynamin on mitochondrial morphology and apoptosis were analyzed, either in fibroblasts from affected individuals, or in HeLa cells transfected with similar mutants. The alleles were missense substitutions in the GTPase domain (OPA1(G300E) and OPA1(R290Q)) or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblasts
Share to GTP Phosphohydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Microscopy, Fluorescence

Share to Mitochondria

Share to Optic Atrophy, Autosomal Dominant

Share to Staurosporine

Source

Identifiers

PMID: 17167772
DOI: 10.1002/jcp.20950

Genes

OPA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of OPA1 mutations on mitochondrial morphology and apoptosis: relevance to ADOA pathogenesis.PMID 17167772Read ↗

Mitochondrial dysfunction in an Opa1(Q285STOP) mouse model of dominant optic atrophy results from Opa1 haploinsufficiency.Semantic proximity Read ↗

OPA1 (dys)functions.Semantic proximity Read ↗

Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy.Semantic proximity Read ↗

OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion.Semantic proximity Read ↗

OPA1: How much do we know to approach therapy?Semantic proximity Read ↗

Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cellsSemantic proximity Read ↗

Changes in Mitochondrial Morphology and Bioenergetics in Human Lymphoblastoid Cells With Four Novel OPA1 Mutations.Semantic proximity Read ↗

Mitochondrial dynamics and disease, OPA1.Semantic proximity Read ↗

OPA1 (Kjer type) dominant optic atrophy: a novel mitochondrial disease.Semantic proximity Read ↗

OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts.Semantic proximity Read ↗

A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis.Semantic proximity Read ↗

A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.