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Article

Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.

Molecular cancer therapeutics - 1 Apr 2010

More Swati S, Li Shuanglian, Yee Sook Wah, Chen Ligong, Xu Zhidong, Jablons David M, Giacomini Kathleen M

Abstract excerpt

Picoplatin, a third-generation platinum agent, is efficacious against lung cancers that are otherwise resistant or become refractory during platinum treatment. This effort was aimed at the determination of the influence of organic cation transporters 1, 2, and 3 (OCT1, OCT2, and OCT3) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as...

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Source

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Identifiers

PMID: 20371711
DOI: 10.1158/1535-7163.MCT-09-1084
PMCID: PMC3258025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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