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Article

Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives.

International journal of molecular sciences - 19 Jan 2022

Eltayeb Sara Ahmed, Ciarimboli Giuliano, Beul Katrin, Seno Di Marco Giovana, Barz Vivien

Abstract excerpt

The human organic cation transporter 2 (hOCT2) mediates renal and neuronal cellular cisplatin and oxaliplatin uptake, and therefore plays a significant role in the development of side effects associated with these chemotherapeutic drugs. Autophagy is induced by cisplatin and oxaliplatin treatment and is believed to promote cell survival under stressful conditions. We examined in vitro the role of hOCT2 on...

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Identifiers

PMID: 35163014
DOI: 10.3390/ijms23031090
PMCID: PMC8834759

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