Article
H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation.
Development (Cambridge, England) - 15 Sept 2017
Li Yeran, Wang Chao, Cai Weili, Sengupta Saheli, Zavortink Michael, Deng Huai, Girton Jack, Johansen Jørgen, Johansen Kristen M
Abstract excerpt
A model has been proposed in which JIL-1 kinase-mediated H3S10 and H2Av phosphorylation is required for transcriptional elongation and heat shock-induced chromatin decondensation. However, here we show that although H3S10 phosphorylation is indeed compromised in the H2Av null mutant, chromatin decondensation at heat shock loci is unaffected in the absence of JIL-1 as well as of H2Av and that there is no...
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