Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2010

Brown Matthew S, Diallo Oumou T, Hu Michael, Ehsanian Reza, Yang Xinping, Arun Pattatheyil, Lu Hai, Korman Vicci, Unger Gretchen, Ahmed Khalil, Van Waes Carter, Chen Zhong

Abstract excerpt

PURPOSE: The aim of this study is to investigate the expression of CK2 subunits and CK2 effects on NF-kappaB-mediated and TP53-mediated signal activation and gene expression, the malignant phenotype, and chemosensitivity in head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo. EXPERIMENTAL DESIGN: Protein expression of CK2 subunits was investigated by Western blot and immunohistochemistry. CK2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Casein Kinase II
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luciferases

Share to Mice, Nude

Share to NF-kappa B

Share to Oligonucleotides, Antisense

Share to RNA, Small Interfering

Share to Wound Healing

Source

Open in PubMed Open full text

Identifiers

PMID: 20371694
DOI: 10.1158/1078-0432.CCR-09-3200
PMCID: PMC2861417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules.PMID 20371694Read ↗

The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cellsSemantic proximity Read ↗

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cellsSemantic proximity Read ↗

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapySemantic proximity Read ↗

CCT2 enhances the proliferation and migration of head and neck squamous cell carcinoma via regulating cell cycleSemantic proximity Read ↗

Response of cancer cells to molecular interruption of the CK2 signal.Semantic proximity Read ↗

Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models.Semantic proximity Read ↗

Casein Kinase 2 Inhibitor, CX-4945, as a Potential Targeted Anticancer Agent in Gastric CancerSemantic proximity Read ↗

CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer.Semantic proximity Read ↗

Activity of CK2α protein kinase is required for efficient replication of some HPV typesSemantic proximity Read ↗

Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damageSemantic proximity Read ↗

Cancer-type dependent expression of CK2 transcriptsSemantic proximity Read ↗

Targeting CK2 in cancer: a valuable strategy or a waste of time?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.