Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells

19 Aug 2010

Abstract excerpt

BACKGROUND: Pancreatic cancer is a complex genetic disorder that is characterized by rapid progression, invasiveness, resistance to treatment and high molecular heterogeneity. Various agents have been used in clinical trials showing only modest improvements with respect to gemcitabine-based chemotherapy, which continues to be the standard first-line treatment for this disease. However, owing to the overwhelming...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Pancreatic and Hepatic Oncology Research
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20718998
DOI: 10.1186/1471-2407-10-440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cellsPMID 20718998Read ↗

The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cellsSemantic proximity Read ↗

Response of cancer cells to molecular interruption of the CK2 signal.Semantic proximity Read ↗

CKS2 Predicts A Poor Prognosis and Contributes to Malignant Progression of Pancreatic CancerSemantic proximity Read ↗

PTEN deficiency facilitates gemcitabine efficacy in cancer by modulating the phosphorylation of PP2Ac and DCKSemantic proximity Read ↗

Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabineSemantic proximity Read ↗

Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.Semantic proximity Read ↗

Intrinsic Chemoresistance to Gemcitabine Is Associated with Decreased Expression of BNIP3 in Pancreatic CancerSemantic proximity Read ↗

Berberine Inhibits Cell Growth and Mediates Caspase-Independent Cell Death in Human Pancreatic Cancer CellsSemantic proximity Read ↗

Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancerSemantic proximity Read ↗

Gemcitabine resistance by CITED4 upregulation via the regulation of BIRC2 expression in pancreatic cancerSemantic proximity Read ↗

Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic CancerSemantic proximity Read ↗

CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.