Article
Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models.
Molecular cancer - 20 Feb 2014
Sobral Lays M, Sousa Lucas O, Coletta Ricardo D, Cabral Hamilton, Greene Lewis J, Tajara Eloiza H, Gutkind J Silvio, Curti Carlos, Leopoldino Andréia M
Abstract excerpt
BACKGROUND: SET/I2PP2A is a multifunctional protein that is up-regulated in head and neck squamous cell carcinoma (HNSCC). The action of SET in HNSCC tumorigenicity is unknown. METHODS: Stable SET knockdown by shRNA (shSET) was established in three HNSCC cell lines: HN12, HN13, and Cal27. Protein expression and phosphorylated protein levels were determined by Western blotting and immunofluorescence, cell...
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