Article
Penetrance of NOD2/CARD15 genetic variants in the general population.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne - 20 Apr 2010
Yazdanyar Shiva, Kamstrup Pia R, Tybjaerg-Hansen Anne, Nordestgaard Børge G
Abstract excerpt
BACKGROUND: In case-control studies of Europeans, heterozygosity for Arg702Trp(rs2066844), Gly908Arg(rs2066845) and Leu1007fsinsC(rs5743293) on the NOD2/CARD15 gene is associated with a 2-fold greater risk of Crohn disease, whereas homozygosity or compound heterozygosity is associated with a 17-fold greater risk. However, the importance of these genetic variants if identified in particular individuals within the...
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