Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure-activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription.

Bioorganic & medicinal chemistry - 1 Dec 2012

Li Bingbing X, Yamanaka Kinrin, Xiao Xiangshu

Abstract excerpt

CREB (cyclic AMP-response element binding protein) is a downstream transcription factor of a multitude of signaling pathways emanating from receptor tyrosine kinases or G-protein coupled receptors. CREB is not activated until it is phosphorylated at Ser133 and its subsequent binding to CREB-binding protein (CBP) through kinase-inducible domain (KID) in CREB and KID-interacting (KIX) domain in CBP. Tumor tissues...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Apoptosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Cyclic AMP Response Element-Binding Protein

Share to Gene Expression Regulation, Neoplastic

Share to Naphthols

Share to Protein Interaction Mapping

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 23102993
DOI: 10.1016/j.bmc.2012.09.056
PMCID: PMC3587690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure-activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription.PMID 23102993Read ↗

Targeting CREB for Cancer Therapy: Friend or FoeSemantic proximity Read ↗

cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric ApproachSemantic proximity Read ↗

CREB in the Pathophysiology of Cancer: Implications for Targeting Transcription Factors for Cancer TherapySemantic proximity Read ↗

Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic targetSemantic proximity Read ↗

Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cellsSemantic proximity Read ↗

Identification and structure-activity relationship studies of 3-methylene-2-norbornanone as potent anti-proliferative agents presumably working through p53 mediated apoptosis.Semantic proximity Read ↗

Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300Semantic proximity Read ↗

Harmine suppresses the proliferation and migration of human ovarian cancer cells through inhibiting ERK/CREB pathwaySemantic proximity Read ↗

Characteristics of the cAMP response unit.Semantic proximity Read ↗

Design and synthesis of anticancer 1-hydroxynaphthalene-2-carboxanilides with a p53 independent mechanism of actionSemantic proximity Read ↗

NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells.Semantic proximity Read ↗

CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.