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Article

Determination of DNA binding specificities of mutated zinc finger domains.

FEBS letters - 20 May 1991

Thiesen H J, Bach C

Abstract excerpt

By substituting non conserved amino acids present in the postulated alpha-helical region of zinc finger domains, we demonstrated that Cys2/His2 type zinc finger domains could be targeted to new DNA binding sites. The putative alpha-helical region of the second SP1 zinc finger (RSDELQRH) was replaced by amino acids (KSSALISH) occurring in analogous zinc finger positions of human zinc finger protein Kox 29. The DNA...

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Identifiers

PMID: 2037068
DOI: 10.1016/0014-5793(91)80545-e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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