Article
LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.
Neurogenetics - 1 Oct 2010
Vilariño-Güell Carles, Wider Christian, Ross Owen A, Jasinska-Myga Barbara, Kachergus Jennifer, Cobb Stephanie A, Soto-Ortolaza Alexandra I, Behrouz Bahareh, Heckman Michael G, Diehl Nancy N, Testa Claudia M, Wszolek Zbigniew K, Uitti Ryan J, Jankovic Joseph, Louis Elan D, Clark Lorraine N, Rajput Alex, Farrer Matthew J
Abstract excerpt
Genetic variation in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was recently associated with an increased risk of developing essential tremor (ET) and Parkinson disease (PD). Herein, we performed a comprehensive study of LINGO1 and its paralog LINGO2 in ET and PD by sequencing both genes in patients (ET, n=95; PD, n=96) and by examining haplotype-tagging single-nucleotide polymorphisms...
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