Variant in the sequence of the LINGO1 gene confers risk of essential tremor.

doi:10.1038/ng.299

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Article

Variant in the sequence of the LINGO1 gene confers risk of essential tremor.

Nature genetics - 1 Mar 2009

Stefansson Hreinn, Steinberg Stacy, Petursson Hjorvar, Gustafsson Omar, Gudjonsdottir Iris H, Jonsdottir Gudrun A, Palsson Stefan T, Jonsson Thorlakur, Saemundsdottir Jona, Bjornsdottir Gyda, Böttcher Yvonne, Thorlacius Theodora, Haubenberger Dietrich, Zimprich Alexander, Auff Eduard, Hotzy Christoph, Testa Claudia M, Miyatake Lisa A, Rosen Ami R, Kristleifsson Kristleifur, Rye David, Asmus Friedrich, Schöls Ludger, Dichgans Martin, Jakobsson Finnbogi, Benedikz John, Thorsteinsdottir Unnur, Gulcher Jeffrey, Kong Augustine, Stefansson Kari

Abstract excerpt

We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the...

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PMID: 19182806
DOI: 10.1038/ng.299
PMCID: PMC3740956

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