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Article

Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response.

Journal of psychiatric research - 1 Aug 2010

Souza Renan P, Romano-Silva Marco A, Lieberman Jeffrey A, Meltzer Herbert Y, MacNeil Lesley T, Culotti Joseph G, Kennedy James L, Wong Albert H C

Abstract excerpt

GDNF (glial-cell-line derived neurotrophic factor) is a potent neurotrophic factor for dopaminergic neurons. Neuropsychiatric diseases and their treatments are associated with alterations in the levels of both GDNF and its receptor family (GDNF family receptor alpha or GFRA). GFRA1, GFRA2 and GFRA3 are located in chromosomal regions with suggestive linkage to schizophrenia. In this study we analyzed polymorphisms...

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Source

Identifiers

PMID: 20116071
DOI: 10.1016/j.jpsychires.2010.01.002

Genes

GFRA1
GDNF
GFRA3
GFRA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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