Article
Combined analysis of 635 patients confirms an age-related association of the serotonin 2A receptor gene with tardive dyskinesia and specificity for the non-orofacial subtype.
The international journal of neuropsychopharmacology - 1 Sept 2005
Lerer Bernard, Segman Ronnen H, Tan Ene-Choo, Basile Vincenzo S, Cavallaro Roberto, Aschauer Harald N, Strous Rael, Chong Siow-Ann, Heresco-Levy Uriel, Verga Massimiliano, Scharfetter Joachim, Meltzer Herbert Y, Kennedy James L, Macciardi Fabio
Abstract excerpt
Tardive dyskinesia (TD) is an important limiting factor in the use of typical antipsychotic drugs. Genetic variability in the serotonin 2A (5-HT(2A)) receptor may influence risk for TD but the results of prior studies are not confirmatory. The objective of this study was to determine association of T102C and His452Tyr polymorphisms in the 5-HT(2A) receptor gene (HTR(2A)) with TD in a large, multicentre patient...
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